Blar i forfatter "Puntervoll, Pål"

Viser treff 1-3 av 3

    • Model of Tryptophan Metabolism, Readily Scalable Using Tissue-specific Gene Expression Data 

      Stavrum, Anne-Kristin; Heiland, Ines; Schuster, Stefan; Puntervoll, Pål; Ziegler, Mathias (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Tryptophan is utilized in various metabolic routes including protein synthesis, serotonin, and melatonin synthesis and the kynurenine pathway. Perturbations in these pathways have been associated with neurodegenerative diseases and cancer. Here we present a comprehensive kinetic model of the complex network of human tryptophan metabolism based upon existing kinetic data for all enzymatic conversions ...

    • Mutational analysis of the pro-peptide of a marine intracellular subtilisin protease supports its role in inhibition 

      Bjerga, Gro Elin Kjæreng; Larsen, Øivind; ARSIN, Hasan; Williamson, Adele Kim; Garcia-Moyano, Antonio; Leiros, Ingar; Puntervoll, Pål (Journal article; Tidsskriftartikkel, 2018-06-16)
      Intracellular subtilisin proteases (ISPs) have important roles in protein processing during the stationary phase in bacteria. Their unregulated protein degrading activity may have adverse effects inside a cell, but little is known about their regulatory mechanism. Until now, ISPs have mostly been described from <i>Bacillus</i> species, with structural data from a single homolog. Here, we study a ...

    • SBMLmod: a Python-based web application and web service for efficient data integration and model simulation 

      Schäuble, Sascha; Stavrum, Anne-Kristin; Bockwoldt, Mathias; Puntervoll, Pål; Heiland, Ines (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-24)
      BACKGROUND: Systems Biology Markup Language (SBML) is the standard model representation and description language in systems biology. Enriching and analysing systems biology models by integrating the multitude of available data, increases the predictive power of these models. This may be a daunting task, which commonly requires bioinformatic competence and scripting. <br>RESULTS: We present ...